Understanding DDET
Preface
It is in the neighborhood of 71 years since the most significant advance was made (in 1941) by Drs. Huggins and Hodges who received the Nobel Prize (in 1966) for medicine when they made the discovery that it was the male body’s production of hormones that fed and proliferated prostate cancer (PC). At that time the only method of treatment was an orchiectomy and the female hormone DES. DES was found to cause cardiovascular disease, thrombo embolism, and phlebitis; more patients died from the treatment rather than the disease. It was abandoned and the methods of treatment – radical prostatectomy, radiation, and later brachytherapy (radioactive seed implants) were givenRead More...
Detection
The first consideration for the Detection of the disease should be involved in the currently, most accurate method, the Prostate Specific Antigen (PSA) blood test, which should be undertaken immediately after a man has had his 40th birthday. In the case where a man has a history of prostate cancer in the family (brother(s), father, grandfather, etc.), early detection is even more important and he should commence annual PSA tests after his 30th birthday. In addition, African American males, who have a 4 times incidence of the disease should also commence PSA detection at 30 years of age. It is better to be safe than sorry. How many patients’ lives could have been extended ifRead More...
Diagnosis
To properly diagnose the condition of the gland, a transrectal ultrasound (TRUS) utilizing the most advanced equipment should be undertaken (preferably by a Doppler Color Enhanced unit which can obtain a superior image, enhancing the hypoechoic echogenicity in suspicious tumor areas that permits a needle GUIDED biopsy rather than the blinded multiple random biopsies). Should a positive biopsy result, further confirmation of the extent of the disease by CT scan and/or a MRI in conjunction with an imaging enhancing agent such as CYT356 should be undertaken. Further blood tests, such as PSA-II, will more clearly define the extent of the disease. Additional data should be obtainedRead More...
Evaluation
In consideration of the knowledge of the patient; the knowledge, capability and experience of the attending physician; and the availability and use of the most up-to-date equipment; a complete evaluation should be undertaken with a written report furnished to the patient outlining ALL treatment options available – not those that serve only the vested interest of the physician. Improvements in ultrasound equipment, namely Doppler Color Enhancement, permits a more definable hypoechoic echogenicity that makes it possible to provide a needle guided biopsy rather than blinded multiple randomized biopsies, which may miss the tumors entirely especially when they are small. ImagingRead More...
Treatment
The most controversial aspects involving prostate cancer are the recommended methods of treatment which may be greatly influenced by the vested interests of the physician, the extent of their knowledge, experience with the treatments of the disease, and their adherence to their Hippocratic Oath. The possession of a MD license or the title of urologist does not insure that the physician is qualified to treat prostate cancer. Early detection is of paramount importance in the successful treatment of this number one cancer killer of men. The notion that we can hold off treatment until symptoms appear is foolhardy and increases the likelihood that the patient’s life span couldRead More...
Alternative Therapies
November 28, 1997, CNN broadcast a half-hour news release on the merits of alternative therapies. The definition of ALTERNATIVE is “Instead of” which advocates a substitute for present acceptable methods of treatment. The definitive conclusion was that the promotion of these alternatives was MEDICAL FRAUD and patients were warned that the news releases and other methods used to influence patients to add to or substitute for proven treatment were invalid. In nearly all cases the same results were attained when NOT using the alternative medications and equipment. It is true that there are self-interested individuals, groups and organizations that will influence the legislativeRead More...
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